C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/12 (2006.01) C07D 241/10 (2006.01)
Patent
CA 2682304
The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino- [5-( l-hydroxy-2-hydroxy or halogen-ethyl) ] -pyrazine derivatives of the formula (formula I) wherein R is lower alkylcarbonyl or an amino protecting group and R1 is hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.
L'invention concerne une réduction biocatalytique asymétrique destinée à la préparation de dérivés de 2-amino- [5-( l-hydroxy-2-hydroxy ou halogène-éthyl) ] -pyrazine de la formule (formule I), dans laquelle R est alkylcarbonyle inférieur ou un groupe protecteur d'amine et R1 est hydroxy ou halogène. Les composés de l'invention sont des intermédiaires clés dans la fabrication d'un activateur de la glucokinase.
Hanlon Steven Paul
Iding Hans
Kupfer Ernst
Radinov Roumen Nikolaev
Shu Lianhe
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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