Microbial synthesis of hiv protease inhibitors

Details Microbial synthesis of hiv protease inhibitors Microbial synthesis of hiv protease inhibitors

C - Chemistry, Metallurgy

12

P

C12P 17/16 (2006.01) A61K 31/495 (2006.01) C07D 401/06 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2203272

Biotransformation products of a fermentation with culture MA7065 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Les produits de biotransformation d'une fermentation avec une culture MA7065 sont de puissants inhibiteurs de la protéase du VIH. Ces produits sont utiles pour la prophylaxie ou le traitement de l'infection par le VIH et le traitement du SIDA, comme composés, sels pharmaceutiquement acceptables, ingrédients de composition pharmaceutique, combinés ou non avec d'autres vaccins. L'invention traite également de procédés de traitements du SIDA et de procédés de prévention ou traitement de l'infection par le VIH.

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