Microbial synthesis of hiv protease inhibitors

Details Microbial synthesis of hiv protease inhibitors Microbial synthesis of hiv protease inhibitors

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 31/495 (2006.01) C07D 401/06 (2006.01) C12P 17/16 (2006.01)

Patent

CA 2203273

Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, phamaceutically composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Des produits de biotransformation d'une fermentation avec une culture de MA7074 sont des inhibiteurs puissants de la protéase de HIV. Ces produits sont utiles dans la prévention ou le traitement de l'infection par HIV et dans le traitement du SIDA, sous forme de composés, de sels pharmaceutiquement acceptables, d'ingrédients de compositions pharmaceutiques, combinés ou non à d'autres agents antiviraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des procédés de traitement du SIDA, ainsi que des procédés de prévention ou de traitement de l'infection par HIV.

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