C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A01N 43/78 (2006.01) A61K 31/425 (2006.01) C07D 493/04 (2006.01) C12P 17/08 (2006.01) C12P 17/10 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2356360
A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
Procédé microbien servant à préparer un épothilone contenant un groupe terminal hydroxyalkyle et consistant à mettre en contact au moins un épothilone possédant un groupe alkyle terminal avec un enzyme ou un micro-organisme capable de catalyser l'hydroxylation sélective dudit groupe alkyle en un groupe hydroxyalkyle, et à effectuer ladite hydroxylation.
Huang Xiaohua
Lam Kin Sing
Li Wenying
Matson James A.
Mcclure Grace A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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