Microbial transformation of 8-chloro-10,11-dihydrodibenz...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/00 (2006.01) C07D 267/20 (2006.01) C12P 17/14 (2006.01)

Patent

CA 1067436

Abstract or the Disclosure 8-Chloro-10,11-dihydrodibenz[b,f][1,4]oxa- zepine is transformed by various microorganism into 2-(2-amino-4-chlorophenoxy)benzyl alcohol and 2-(2- acetamido-4-chlorophenoxy)benzyl acetate. Among the microorganisms useful for this purpose are Trichoderma lignorum sp. NRRL 8138, Hormodendrum sp. NRRL 8133, Cladosporium lignicolum sp. NRRL 8131, Hormodendrum cladosporioides sp. NRRL 8132, Pullularia pullulans sp. NRRl 8137, Penicillium sp NRRL 8136, Mucor sp. NRRL 8135, Chaetomium sp. NRRL 8130, and Hormodendrum sp. NRRL 8134. The compounds of the instant invention possess utility as smooth muscle antagonist.

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