Microbial transformation process for antihypertensive products

Details Microbial transformation process for antihypertensive products Microbial transformation process for antihypertensive products

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2041763

9/CSQ1 181191A TITLE OF THE INVENTION MICROBIAL TRANSFORMATION PROCESS FOR ANTIHYPERTENSIVE PRODUCTS ABSTRACT OF THE DISCLOSURE Fermentation of the microorganism Actinoplanacete sp. in the presence of the Angiotensin II (A II) receptor antagonist Image 9/CSQl - i - 18119IA yields a 5-hydroxymethyl and a 7-hydroxymethyl analog, both of which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

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