Microbial transformation product

Details Microbial transformation product Microbial transformation product

C - Chemistry, Metallurgy

07

D

167/209, 260/237

C07D 498/04 (2006.01) A61K 31/44 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C12P 1/06 (2006.01)

Patent

CA 2007679

7043P/5292A 1/06/89:F1 17832 TITLE OF THE INVENTION NEW MICROBIAL TRANSFORMATION PRODUCT ABSTRACT OF THE DISCLOSURE Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,690, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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