Microbial transformation product of l-683,590

Details Microbial transformation product of l-683,590 Microbial transformation product of l-683,590

C - Chemistry, Metallurgy

12

P

167/209, 195/89,

C12P 17/00 (2006.01) A61K 31/44 (2006.01) C07D 498/04 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C12P 1/06 (2006.01)

Patent

CA 2007680

7145P/5292A 1/11/89:Fl 17854 TITLE OF THE INVENTION MICROBIAL TRANSFORMATION PRODUCT OF L-683,590 ABSTRACT OF THE DISCLOSURE Described is a new immunosuppressant, L-685,487, a monodemethylated rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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