Microbially expressed portions of a monoclonal antibody...

Details Microbially expressed portions of a monoclonal antibody... Microbially expressed portions of a monoclonal antibody...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2043620

TITLE OF THE INVENTION MICROBIALLY EXPRESSED PORTIONS OF A MONOCLONAL ANTIBODY BLOCK RHINOVIRUS ATTACHMENT TO CELL RECEPTORS ABSTRACT OF THE INVENTION Complementary DNA (cDNA) fragments encoding the Fab and Fv portion of the light and heavy chains of a murine monoclonal antibody (mAb) were prepared from hybridoma messenger RNA (mRNA). The mAb is specific for the intercellular adhesion molecule-1 (ICAM-1). Furthermore, the mAb blocks the attachment of human rhinovirus (HRV) particles to their cellular receptor, ICAM-1 Fab and Fv cDNA were molecularly cloned and expressed in a recombinant host, purified, and shown to be biologically active in that they bind to ICAM-1, and block attachment of ligands to ICAM-1, including HRV.

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