Microbiological oxidation process

C - Chemistry – Metallurgy – 12 – N

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195/130, 195/33.

C12N 9/02 (2006.01) C12P 1/00 (2006.01) C12P 7/02 (2006.01) C12P 7/04 (2006.01) C12P 7/06 (2006.01) C12P 7/16 (2006.01) C12P 7/24 (2006.01) C12P 17/02 (2006.01)

Patent

CA 1215333

ABSTRACT OF THE DISCLOSURE The soluble fractions of facultative organisms grown on C1 compounds are capable of oxidizing organic compounds in the presence of a cofactor system compris- ing NADH2 or NADPH2. The soluble fraction is obtained by aerobically growing the microorganism in a fermentor under continuous gassing with a mixture of a C1 compound and air and, initially, carbon dioxide before harvesting. Preferably, the C1 compound is methane. One facultative organism which is useful in the microbiological oxidation of oxidizable organic substrates is Methylobacterium organophilum (CRL.26, NRRL B-11,222). This newly discovered and isolated methylotrophic microorganism strain and its natural and/or artificial mutants grow well under aerobic conditions in a culture medium in the presence of a C1 compound as the major carbon and energy source.

423049

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