Microbiological process for preparing...

Details Microbiological process for preparing... Microbiological process for preparing...

C - Chemistry, Metallurgy

12

P

195/129, 195/84

C12P 1/00 (2006.01) C12N 9/00 (2006.01)

Patent

CA 1038785

ABSTRACT The conversion of a 2-substituted-cyclopentane-1,3,4 -trione or a 2-substituted-3-alkoxy-cyclopent-2-ene -1,4-dione substrate to a 2-substituted-4(R)-hydroxy -cyclopentane-1,4-dione by a microorganism of the class Ascomycetes is improved by: incubation of the micro- organism in a medium having a minimum carbohydrate concen- tration of from 0.1% to 1% and a pH of from 4 to 5 until a concentration of microorganism of 20% to 35% is obtained in the medium; subsequent addition of substrate at a rate of from 0.4 gram to 1.0 gram per hour per 10 liters of mediums; and maintenance of the carbohydrate concentra- tion and pH of the medium during the incubation and addition steps.

214057

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