C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) C07D 309/30 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01)
Patent
CA 2098698
The invention refers to a new a microbial process for preparing .beta.,.delta.-dihydroxy-7- [1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]- heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro- 2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), Image (I) Image (II) by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obsecurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25 to 30°C and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.
L'invention concerne un nouveau procédé microbien pour préparer la delta-lactone de l'acide bêta,delta-dihydroxy-7- [1,2,6,7,8,8a-hexahydro-2,6-diméthyl-8-(2-méthyl-butyryloxy)-naphtalén-1-yl]- heptanoïque de formule (I) et de l'acide bêta,delta-dihydroxy-7-[1,2,6,7,8,8a-hexahydro- 2,6-diméthyl-8-(2-méthylbutyryloxy)-naphtalén-1-yl]-heptanoïque de formule (II), Image (I) Image (II) par fermentation aérobie de la culture submergée d'une souche d'un champignon imparfait biosynthétisant les composés ci-dessus, dans un milieu nutritif contenant des sources de carbone et d'azote utilisables ainsi que des sels minéraux, et par isolement du produit de formule (I), qui comprend la culture d'une souche de la nouvelle espèce de champigon Aspergillus obsecurus produisant le (ou les) composé(s) ci-dessus de formule (I) et/ou (II), dans une étendue de température de 25 à 30 degrés C, suivie, au besoin, de la séparation du (ou des) produit(s) formé(s) du bouillon de fermentation, de l'isolement du (ou des) produit(s) dans la forme lactone de formule (I) et, au besoin, de leur purification.
Ambrus Gabor
Andor Attila
Cseke Laszlo
Erdei Janos
Halasz Edit
Biogal Gyogyszergyar Rt
Fetherstonhaugh & Co.
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