Microbiological process for the production of...

C - Chemistry – Metallurgy – 12 – P

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C12P 35/00 (2006.01) C07D 501/20 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2095166

ABSTRACT OF THE DISCLOSURE Microorganisms are selected for the ability to utilize lactone of the formula: Image I and soluble salts thereof, as the sole carbon, nitrogen and energy source via malonyl-lactone of the formula: Image II and soluble salts thereof, without catabolism of the latter. Further, a microbiological process is disclosed for the production of a malonyl-7-aminocephalosporanic acid derivative of the general formula: Image III or a soluble salt thereof, wherein R represents a hydrogen atom, a hydroxyl group or an acetoxy group, from a cephalosporin C derivative of the general formula: Image IV or a soluble salt thereof, wherein R has the above-stated meaning. Also a new process is described for the conversion of a malonyl-7-amino-cephalosporanic acid derivative to a 7-aminocephalosporanic acid derivative of the general formula: Image V or a soluble salt thereof, wherein R has the above-stated meaning.

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