Microbiological process for the production of hydroxylated...

C - Chemistry – Metallurgy – 12 – P

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C12P 17/12 (2006.01) C07D 241/18 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2055125

ABSTRACT OF THE DISCLOSURE A novel strain of microorganism capable of growing with pyrazine as the sole carbon, nitrogen and energy source is disclosed. These microorganisms hydroxylate pyrazine derivatives of general formula: Image (I) wherein R1 represents a hydrogen or halogen atom and R2 and R3 each represents a hydrogen atom or a lower alkyl group, to form hydroxylated pyrazine derivatives of general formula: Image (II) and the latter are accumulated in the growth medium. A process for the production of hydroxylated pyrazine derivatives is also disclosed.

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