Microbiological synthesis of .beta. endorphin

Details Microbiological synthesis of .beta. endorphin Microbiological synthesis of .beta. endorphin

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.3

C12N 15/00 (2006.01) C07K 14/675 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1182407

ABSTRACT OF THE DISCLOSURE DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of .beta.-lipotropin and including the entire coding region for .beta.-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expression transfer vector, and expressed as a fusion protein. The fusion protein was further modified in vitro to yield mature .beta.-endorphin. .beta.-endorphin was purified from a bacterial lysate. The structure and biological activity of the resulting product was proven by immunological assay, and by two independent assays designed to demonstrate biological activity.

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