Microbubble precursors and methods for their production and use

Details Microbubble precursors and methods for their production and use Microbubble precursors and methods for their production and use

A - Human Necessities

61

K

167/46

A61K 49/00 (2006.01) A61B 8/00 (2006.01) A61B 8/06 (2006.01) A61K 49/22 (2006.01) G01N 33/483 (2006.01)

Patent

CA 1170569

"MICROBUBBLE PRECURSORS AND METHODS FOR THEIR PRODUCTION AND USE" ABSTRACT OF THE DISCLOSURE Microbubbles are formed in a liquid, e.g., blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted there- through, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

390275

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