B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 13/02 (2006.01) A01N 1/02 (2006.01) A61K 9/50 (2006.01) B01J 2/00 (2006.01) B01J 13/04 (2006.01) C12M 1/40 (2006.01) C12M 3/06 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 11/04 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2180742
Spherical microcapsules (38) containing tissue or living cells are formed with a diameter of less than 300 µm using an air knife (2) constructed according to the present invention. The air knife includes a needle (14) and an air sleeve (26) positioned eccentrically around the needle. An alginate solution containing the biological material to be encapsulated is forced through the needle, while pressurized air is introduced into the air sleeve. The pressurized air breaks up the alginate being discharged from the needle. The resultant alginate droplets (34) fall into a collecting tank (4) where they contact a gelling medium (36), such as CaC12, so that the outer surface of these droplets harden and microcapsules are formed. In addition to being eccentrically positioned to facilitate very small droplet formation, the needle preferably has a beveled, pointed discharge end (50) to enhance droplet size reduction.
Procédé de fabrication de microcapsules (38) contenant des cellules de tissus ou de cellules vivantes d'un diamètre de moins de 300 µm utilisant un sectionneur à jet d'air également objet de la présente invention. Le sectionneur à jet d'air comporte une aiguille (14) et un manchon (26) placé excentriquement autour de l'aiguille. Une solution d'alginate contenant le matériel biologique à encapsuler est forcé dans l'aiguille tandis que de l'air sous pression est introduit dans le manchon. Les gouttelettes résultantes d'alginate (34) tombent dans un réservoir de recueuil (4) où elles entrent en contact avec un milieu gélogène (36) tel que du Ca Cl2, qui durcit la surface extérieure des gouttelettes et forme des microcapsules. Outre sa position excentrée qui favorise la production de gouttelettes très fines, l'aiguille présente une extrémité d'évacuation en biseau (50) qui contribue à renforcer la reduction de taille desdites gouttelettes.
Cochrum Kent C.
Dorian Randel E.
Metabolex Inc.
Smart & Biggar
The Regents Of The University Of California
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