Microcrystalline cellulose cushioning granules

Details Microcrystalline cellulose cushioning granules Microcrystalline cellulose cushioning granules

C - Chemistry, Metallurgy

08

J

C08J 3/12 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) C08L 1/04 (2006.01)

Patent

CA 2391243

Granulation of microcrystalline cellulose with a granulating fluid consisting of water and a water-miscible, volatile, polar organic solvent yields porous granules which are comprised of particles that are larger than the ungranulated microcrystalline cellulose. This granulated microcrystalline cellulose is capable of cushioning controlled release particles and barrier coated particles from the compression forces used in tableting, thereby maintaining the physical integrity of the components of the tablet.

La formation de cellulose microcristalline sous forme de granules avec un fluide assurant la formation de granules qui contient de l'eau et un solvant polaire, volatil et miscible avec l'eau, produit des granules poreux constitués de particules qui sont plus grosses que la cellulose microcristalline sous une forme non granulée. Les granules de cellulose microcristalline peuvent amortir des particules à libération régulée et protéger des particules enduites contre l'effet des forces de compression utilisées lors de la fabrication des comprimés, ceci préservant l'intégrité physique des constituants du comprimé.

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