Microcrystalline matrix for controlled administration of...

Details Microcrystalline matrix for controlled administration of... Microcrystalline matrix for controlled administration of...

A - Human Necessities

61

M

167/114, 167/322

A61M 5/14 (2006.01) A61J 1/00 (2006.01) A61K 9/20 (2006.01) A61M 1/02 (2006.01) A61M 1/28 (2006.01)

Patent

CA 1339089

Medical solution is passed in a conduit across a solid, microcrystalline mass of beneficial agent to cause the beneficial agent to dissolve in the medical solution. The beneficial agent comprises a mass of citrate or mannitol in a substantially anhydrous form, the mass being shaped and proportioned 80 that a controlled amount of the beneficial agent dissolves into passing medical solution in a manner that is substantially predetermined. For example, the beneficial agent can dissolve in substantially uniform manner, whereby no substantial portion of the medical solution, such as blood or another parenteral solution, is exposed at a relatively constant flow to a significantly higher concentration of the beneficial agent than other flowing portions of the medical solution. The citrate or mannitol mass of the beneficial agent may include at least one added effective agent for dissolving in the medical solution as the citrate or mannitol dissolves therein.

582995

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