Microdose therapy of female sexual dysfunction by no, co,...

Details Microdose therapy of female sexual dysfunction by no, co,... Microdose therapy of female sexual dysfunction by no, co,...

A - Human Necessities

61

K

A61K 31/5377 (2006.01) A61K 31/04 (2006.01) A61K 31/198 (2006.01) A61K 31/21 (2006.01) A61K 31/295 (2006.01) A61K 31/34 (2006.01) A61P 15/02 (2006.01)

Patent

CA 2294480

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET), are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

On décrit des méthodes de traitement d'affections vasculaires associées à un déséquilibre localisé du tonus vasculaire considéré, en principe de base, comme étant largement imputable à une endothéline (ET) élevée. Ces méthodes consistent en l'administration de monoxyde d'azote (NO), d'agents capables d'apporter du NO (donneurs de NO, par exemple), d'agents activant la guanyl-cyclase (tels que YC-1), ou d'agents prolongeant l'action d'un NO endogène ou d'un acide guanosine monophosphorique (cGMP; une deuxième molécule messagère), tels que des inhibiteurs de phosphodiestérase (PDE). Selon l'invention, lesdits agents sont administrés en doses minimales ou microdoses par n'importe quelle voie connue dans la technique capable d'acheminer des doses comprises entre environ la moitié et un-vingtième (1/2 à 1/20) des doses aptes à induire une vasodilatation dans des voies circulatoires "normales". L'administration de ces agents à faibles doses rétablit l'équilibre du tonus vasculaire sans provoquer quasiment aucun effet systémique dans le système vasculaire, et soulage effectivement des affections vasculaires associées à une réduction de la production de NO ou à une atténuation de l'effet du NO.

Affiliated with

Also associated with

Rating

Microdose therapy of female sexual dysfunction by no, co,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microdose therapy of female sexual dysfunction by no, co,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microdose therapy of female sexual dysfunction by no, co,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1378016