Microemulsion preparation containing a slightly absorbable...

A - Human Necessities – 61 – K

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A61K 47/00 (2006.01) A61K 9/107 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160681

Microemulsion preparation in which a plurality of specified surfactants are combined such that aqueous-phase droplets that contain a physiologically active substance of low absorption and which have an average size of 0.4 - 100 nm are dispersed in an oil-phase dispersion medium. In order to improve its low transdermic or transmucosal absorbability, the physiologically active substance is allowed to be present as dissolved in the aqueous-phase droplets in the W/O emulsion. The preparation is low in local irritation and uses neither malodorous substances such as higher alcohols nor conventional absorption enhancers.

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