Microemulsions as precursors to solid nanoparticles

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/107 (2006.01) A61K 9/51 (2006.01) A61K 33/24 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2445125

The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.

La présente invention concerne la préparation de nouvelles micro-émulsions utilisables en tant que précurseurs de nanoparticules solides. Les micro-émulsions précurseurs sont constituées soit de micro-émulsions d'alcool dans du fluorocarbure, des micro-émulsions d'hydrocarbure liquide dans du fluorocarbure, ou des micro-émulsions d'hydrocarbure liquide dans l'eau. Les nanoparticules ainsi formées présentent des diamètres inférieurs à 200 nanomètres et peuvent servir à l'encapsulation de divers matériaux comprenant des médicaments, des aimants, et des capteurs. Les nanoparticules solides peuvent servir à cibler diverses cellules dans le corps par l'inclusion d'un ligand de ciblage spécifique de cellules. L'invention concerne également des procédés de préparation de nouvelles micro-émulsions précurseurs et des procédés de cuisson de nanoparticules.

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