A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2363141
Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(.alpha.-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a poly-orthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
L'invention porte sur des microparticules à surface adsorbante, leur procédé de fabrication et leurs utilisations. Lesdites microparticules, d'un polymère tel qu'un acide poly(.alpha.-hydroxy), un acide polyhydroxy butyrique, un polycaprolactone, un polyorthoester, un polyanhydride, et analogues, s'obtiennent à l'aide de détergents cationiques, anioniques, ou non ioniques. La surface des microparticules adsorbe efficacement les macromolécules biologiquement actives telles que l'ADN, les polypeptides, les antigènes, et les adjuvants. L'invention porte également sur des compositions d'émulsions de gouttelettes d'huile faites d'une huile métabolisable et d'un émulsifiant, sur des compositions immunogènes comportant une dose immunostimulante d'un antigène, et une quantité immunostimulante d'un adjuvant. L'invention porte en outre sur des procédés de stimulation d'une réponse immunitaire, sur des procédés d'immunisation d'un animal hôte contre une infection virale bactérienne ou parasitaire, et sur des procédés augmentant la réponse immunitaire au Th1 chez un animal hôte par administration d'une composition immunogène comprenant les microparticules et/ou de microémulsions de l'invention.
Barackman John
Donnelly John
Kazzaz Jina
O'hagan Derek
Ott Gary S.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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