Microencapsulated compositions for endoluminal tissue...

A - Human Necessities – 61 – L

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A61L 27/38 (2006.01) A61L 27/58 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2614734

A tissue engineering composition adapted for application to an interior surface of a body lumen of a patient. The composition comprises (a) a carrier medium that is adapted to flow and to stably adhere the composition to the body lumen and (b) microcapsules, which are dispersed within the carrier medium and which contain one or more living cells encapsulated within a coating that includes a biodegradable polymer. The composition promotes growth of the cells on the lumen surface subsequent to application of the composition to the lumen.

L'invention concerne une composition de génie tissulaire conçue pour être appliquée sur une surface intérieure d'une lumière corporelle d'un patient. La composition comprend : (a) un milieu excipient conçu pour s'écouler et adhérer de manière stable la composition à la lumière corporelle et des (b) micro-capsules dispersées dans le milieu excipient et renfermant une ou plusieurs cellules vivantes encapsulées dans un enrobage renfermant un polymère biodégradable. La composition favorise la croissance des cellules sur la surface de la lumière suite à l'application de la composition sur la lumière.

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