Microencapsulated dna for vaccination and gene therapy

Details Microencapsulated dna for vaccination and gene therapy Microencapsulated dna for vaccination and gene therapy

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/70 (2006.01) A61K 39/15 (2006.01) A61K 39/165 (2006.01) A61K 47/10 (2006.01) A61K 47/34 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2236925

A microparticle contains DNA coding for a polypeptide and oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.

L'invention se rapporte à une microparticule contenant de l'ADN codant pour un polypeptide et l'administration par voie orale de cette microparticule qui conduit à son expression. L'ADN codant pour un immunogène est destiné à stimuler la formation d'anticorps chez un receveur, et l'ADN codant pour un polypeptide non-immunogène est destiné à être appliqué en thérapie génique. L'ADN est introduit dans la microparticule sans destruction de sa fonction.

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