Microencapsulated fluorinated gases for use as imaging agents

Details Microencapsulated fluorinated gases for use as imaging agents Microencapsulated fluorinated gases for use as imaging agents

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 8/00 (2006.01) A61K 49/22 (2006.01) B01J 13/12 (2006.01)

Patent

CA 2247151

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

Cette invention concerne l'incorporation de gaz fluorés, notamment d'un perfluorocarbone tel qu'un octafluoropropane, dans des microparticules polymères synthétiques, laquelle incorporation permet d'accroître sensiblement l'échogénicité par rapport aux particules dans lesquelles de l'air a été incorporé. Ces particules de perfluorocarbone micro-encapsulé sont fabriquées de manière à posséder un diamètre acceptable en ce qui concerne les tissus cibles devant être analysés par imagerie, par exemple, lors d'une administration intraveineuse ou orale. Un mode de réalisation consiste à produire des microparticules bio-adhésives permettant d'améliorer la qualité d'imagerie de surfaces de muqueuses.

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