Microencapsulation of living tissue and cells

Details Microencapsulation of living tissue and cells Microencapsulation of living tissue and cells

C - Chemistry, Metallurgy

12

N

167/322, 195/34.

C12N 5/00 (2006.01) A61F 2/02 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 35/12 (2006.01) A61L 27/20 (2006.01) A61L 27/38 (2006.01) C12N 11/04 (2006.01) C12N 11/10 (2006.01) G01N 15/14 (2006.01)

Patent

CA 1215922

ABSTRACT OF THE DISCLOSURE Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane based on polylysine which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which, combined with a controlled thickness of polylysine of molecular weight from 10,000 to 30,000 daltons, imparts to the microcapsules the ability to maintain long term effectiveness.

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