Microencapsulation process using supercritical fluids

B - Operations – Transporting – 01 – J

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B01J 13/02 (2006.01) A61K 9/16 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2267350

The present invention comprises a method for microencapsulating a core material comprising the steps of a) mixing a core material with an encapsulating polymer, b) supplying to the mixture a supercritical fluid capable of swelling the polymer under a temperature and a pressure sufficient to maintain the fluid in a supercritical state, c) allowing the supercritical fluid to penetrate and liquefy the polymer while maintaining temperature and pressure sufficient to maintain the fluid in a supercritical state, and d) rapidly releasing the pressure to solidify the polymer around the core material to form a microcapsule. This method requires neither that the polymer nor core materials be soluble in the supercritical fluid and can be used to rapidly and efficiently microencapsulate a variety of materials for a variety of applications.

La présente invention concerne un procédé de microencapsulation d'une substance coeur, ce procédé consistant à a) mélanger une substance coeur avec un polymère d'encapsulation; b) introduire dans le mélange un fluide supercritique capable de gonfler le polymère à une température et une pression suffisantes de façon à maintenir le fluide à un état supercritique; c) permettre au fluide supercritique de pénétrer dans le polymère et de le liquéfier tout en maintenant le fluide à un état supercritique; et d) relâcher rapidement la pression pour solidifier le polymère autour de la substance coeur et former une microcapsule. Ce procédé ne nécessite ni que le polymère, ni que les substances coeur soient solubles dans le fluide supercritique, et il peut être utilisé pour microencapsuler rapidement et efficacement différentes substances dans une variété d'applications.

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