Microfabricated differential extraction device and method

G - Physics – 01 – N

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G01N 1/00 (2006.01) B01F 13/00 (2006.01) B01J 19/00 (2006.01) G01N 1/40 (2006.01) G01N 15/06 (2006.01) G01N 30/00 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2222126

This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Cette invention concerne un système d'extraction miniaturisé et des procédés d'extraction de particules désirées provenant d'un courant d'échantillons contenant des particules désirées et non désirées. Le courant d'échantillons est mis en contact avec un courant d'extraction dans un flux laminaire dans des conditions où les effets d'inertie sont négligeables. Le contact entre les deux courants est maintenu sur une durée suffisante pour permettre le transport différentiel des particules désirées du courant d'échantillons au courant d'extraction. Selon un mode préféré de réalisation, le mécanisme utilisé pour le transport différentiel est le mécanisme de diffusion. Le système d'extraction de cette invention couplé à un dispositif de mélange miniaturisé basé sur la diffusion et/ou à un détecteur permet de traiter ou d'analyser des quantité de fluide mesurées en picolitres sur des dispositifs dont la taille est inférieure à celle des tranches de silicium.

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