Microfabricated nanopore device for sustained release of...

A - Human Necessities – 61 – M

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A61M 31/00 (2006.01) A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 9/58 (2006.01) A61L 27/02 (2006.01) A61L 27/14 (2006.01) A61L 27/54 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2460334

A drug delivery device that includes a capsule for implantation into the body ; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.

L'invention concerne un dispositif d'administration de médicaments comprenant une capsule à implanter dans un corps, cette capsule étant dotée d'un réservoir contenant une substance telle qu'un agent thérapeutique, au moins un port permettant à la substance de se répandre dans le réservoir ou alors d'en sortir, et une membrane nanoporeuse en communication avec la capsule au niveau du ou près du port d'évacuation afin de contrôler la vitesse de répartition de la substance depuis le port d'évacuation. Ce dispositif comporte également un grillage facultatif afin de garantir une stabilité structurelle à la membrane nanoporeuse et afin de garder les pores de la membrane nanoporeuse propres. Dans un mode de réalisation du dispositif d'administration de médicaments, ce dernier est équipé d'un moteur osmotique interne afin de créer un courant de fluide qui traverse le dispositif.

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