Microfluidic devices connected to capillaries with minimal...

H - Electricity – 01 – J

Patent

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Details

H01J 49/04 (2006.01) B01L 3/00 (2006.01) G01N 27/447 (2006.01) G01N 30/60 (2006.01) G01N 30/72 (2006.01)

Patent

CA 2386056

A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.

Cette invention concerne un procédé qui permet de joindre un dispositif à micropuce à un tube capillaire. Le dispositif à micropuce comprend un canal capillaire qui s'ouvre sur une de ses surfaces latérales. Un trou court est foré dans la surface latérale en alignement avec le canal capillaire. Le forage se fait de manière à obtenir un fond plat, de préférence selon un procédé de forage en deux étapes. L'extrémité du capillaire peut ensuite être insérée dans le trou de sorte que son extrémité affleure le fond plat dudit trou, ce qui permet d'éliminer tout volume inutilisé. Les tests ont prouvé que cette connexion n'offre qu'un très faible élargissement de bande des échantillons transportés dans le canal capillaire jusque dans le tube capillaire. L'extrémité du tube capillaire peut être conique de sorte qu'il puisse être utilisé comme source d'électronébulisation dans un spectromètre de masse.

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