Microfluidization of calcium/oxyanion-containing particles

A - Human Necessities – 61 – K

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A61K 51/12 (2006.01) A61K 49/00 (2006.01) A61K 51/02 (2006.01)

Patent

CA 2187749

Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small ( 5µm) and uniform particles to be formed. Coating and purifying (especially by tangential flow filtration) the particles improves particle stability.

L'invention concerne l'utilisation d'un appareil de microfluidisation pour la préparation de particules solides d'apatite utilisables en imagerie médicale pour des diagnostics, faisant appel, par exemple, à la résonance magnétique nucléaire, aux rayons X ou aux ultrasons. On synthétise les particules souhaitées d'apathie, on les traite dans un appareil de microfluidisation et on les purifie pour enlever l'excès de base, de sels et d'autres produits utilisés pour la synthèse des particules. L'appareil de microfluidisation provoque l'interaction de deux jets à des vitesses extrêmement élevées, dans un microcanal délimité avec précision. La microfluidisation des préparations provoque la formation de particules uniformes de petite taille (? 5 µm). L'application d'un revêtement et une purification (en particulier par une filtration à flux tangentiel) améliorent la stabilité des particules.

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