Microgranules containing cisplatin

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/24 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/28 (2006.01) A61K 31/282 (2006.01) A61K 47/30 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2282082

The invention concerns a novel formulation of cisplatin, for oral administration, in the form of microgranules with controlled release, and its method of preparation by grossing in an aqueous medium. The invention also concerns a pharmaceutical preparation containing cisplatin microgranules with controlled release and anticancer agent as combination product to be used simultaneously, separately or at different times in anticancer therapy, and the use of said microgranules for making medicine to be orally administered for use in polychemotherapy or in combination with radiotherapy.

La présente invention concerne une nouvelle formulation du cisplatine, pour administration orale, sous forme de microgranules à libération contrôlée, ainsi que son procédé de préparation par montage en milieux aqueux. Elle concerne également une préparation pharmaceutique contenant les microgranules de cisplatine à libération contrôlée et un agent anticancéreux comme produit de combinaison pour une utilisation simultanée, séparée ou étalée dans le temps en thérapie anticancéreuse, ainsi que l'utilisation desdits microgranules pour fabriquer un médicament à administrer par voie orale destiné à être utilisé en polychimiothérapie ou en association avec une radiothérapie.

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