A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)
Patent
CA 2707969
Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10 ? or less than or equal to 20 ? are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.
La présente invention a pour objet de nouvelles compositions, formulations et formes pharmaceutiques comprenant des particules d'opioïde micronisées stabilisées. Des exemples d'opioïdes comprennent l'oxycodone, l'oxymorphone, l'hydrocodone, et l'hydromorphone, y compris sous forme de bases libres ou de sels. Sont décrites des particules d'opioïde micronisées stabilisées ayant une distribution de la taille des particules Dv90 inférieure ou égale à 10 µ ou inférieure ou égale à 20 µ. Des procédés permettant de microniser un opioïde pour fournir des particules d'opioïde micronisées stabilisées sont également décrits.
Blasko Andrei
Chou De-Hwa
Fu Cherng-Chyi
Yum Su Il
Zamloot Michael
Mbm Intellectual Property Law Llp
Pain Therapeutics Inc.
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