Micronized tanaproget, compositions, and methods of...

A - Human Necessities – 61 – K

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Details

A61K 31/536 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2603806

The present invention provides compositions, desirably pharmaceutical compositions, containing micronized tanaproget. The compositions can also contain microcrystalline cellulose, croscarmellose sodium, anhydrous lactose, magnesium stearate, micronized edetate calcium disodium hydrous, and micronized sodium thiosulfate pentahydrate. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.

La présente invention concerne des compositions, des compositions de préférence pharmaceutiques contenant du tanaproget micronisé. Les compositions peuvent également contenir du cellulose microcristallin, du sodium de croscarmellose, du lactose anhydre, du stéarate de magnésium, du sel disodique d'édétate de calcium hydraté micronisé, et du pentahydrate de thiosulfate de sodium micronisé. Les compositions sont utiles dans le cadre de la contraception et de la thérapie de remplacement hormonal, et dans le cadre du traitement et/ou de la prévention de fibroïdes du myomètre utérin, l'hypertrophie prostatique bénigne, la maladie néoplasique bénigne ou maligne, les saignements anormaux, le leiomyomata utérin, l'endométriose, le syndrome ovarien polycystique et des carcinomes et adénocarcinomes de l'hypophyse, de l'endomètre, du rein, de l'ovaire, du sein, du colon et de la prostate, et d'autres tumeurs hormono-dépendantes, et dans le cadre de la préparation de médicaments utiles à cet effet. D'autres utilisations comprennent la stimulation de l'absorption d'aliments.

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