C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 31/445 (2006.01) C07H 19/01 (2006.01) C12P 19/44 (2006.01)
Patent
CA 2074861
177/RJN115 18501Y TITLE OF THE INVENTION NEW MICROORGANISM FOR PRODUCING C-31 DESMETHYL FR-900520 CYCLIC HEMIKETAL IMMUNOSUPPRESSANT AGENT ABSTRACT OF THE DISCLOSURE Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylatecl devivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-des- methylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide 177/RJN115 - i - 18501Y immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
Arison Byron H.
Chen Shieh-Shung T.
Colwell Lawrence F. Jr.
Dumont Francis
Gagliardi Magda M.
Arison Byron H.
Chen Shieh-Shung T.
Colwell Lawrence F. Jr.
Dumont Francis
Gagliardi Magda M.
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