Microorganism, lactamase enzyme obtained therefrom, and...

Details Microorganism, lactamase enzyme obtained therefrom, and... Microorganism, lactamase enzyme obtained therefrom, and...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C12N 9/86 (2006.01) C12P 13/00 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2264651

A lactamase enzyme having good stability, capable of hydrolysing an enantiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino-acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isolated and cloned, and its structure identified.

On a trouvé dans une souche de Comamonas acidivorans un enzyme lactamase ayant une bonne stabilité et capable d'hydrolyser un énantiomère du lactame à cycle double, 2-azabicyclo[2.2.1]hept-5-ène-3-one, pour donner un lactame (-) et un amino-acide (+). L'enzyme a été isolé et cloné et sa structure identifiée.

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