C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/02 (2006.01) C12N 1/21 (2006.01)
Patent
CA 2491145
The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
La présente invention porte sur des procédés améliorés de production plus rentable de pantoate et pantothénate utilisant des micro-organismes dont les activités enzymatiques biosynthétiques du pantothénate sont modifiées et dont les activités enzymatiques biosynthétiques du méthylènetétrahydrofolate (MTF) sont modifiées. L'invention porte, plus particulièrement, sur des procédés de perfectionnement de la production de produits souhaités par augmentation des niveaux d'un intermédiaire clé, le cétopantoate, et par l'augmentation d'enzymes ou de substrats contribuant directement ou indirectement à sa synthèse. Font également l'objet de cette invention des micro-organismes recombinants et des conditions de leur mise en culture ainsi que des compositions obtenues au moyen de ces micro-organismes.
Hermann Theron
Patterson Thomas A.
Pero Janice G.
Yocum R. Rogers
Basf Aktiengesellschaft
Robic
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