Microorganisms and processes for enhanced production of...

Details Microorganisms and processes for enhanced production of... Microorganisms and processes for enhanced production of...

C - Chemistry, Metallurgy

12

P

C12P 13/02 (2006.01) C07C 235/12 (2006.01) C12N 9/04 (2006.01) C12N 9/10 (2006.01) C12N 15/03 (2006.01)

Patent

CA 2434626

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

L'invention concerne des procédés améliorés permettant une production plus importante de pantoate et de pantothénate par l'utilisation de micro-organismes dont les activités des enzymes de biosynthèse de pantothénate et de méthylènetétrahydrofolate (MTF) ont été modifiées. L'invention concerne en particulier des procédés permettant d'augmenter la production de produits recherchés par augmentation des teneurs d'un intermédiaire clé, du cétopantoate, au moyen d'enzymes qui contribuent à sa synthèse. Elle concerne encore des micro-organismes recombinants et des conditions de leur culture. Elle concerne enfin des compositions produites par ces micro-organismes.

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