C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) C12N 1/00 (2006.01) C12N 15/00 (2006.01) C12N 15/52 (2006.01) C12P 7/40 (2006.01) C12N 9/00 (2006.01)
Patent
CA 2722680
The invention provides a non-naturally occurring microbial organism having a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
L'invention concerne des organismes microbiens non naturels qui ont une voie de synthèse d'acide 2-hydroxyisobutyrique, d'acide 3-hydroxyisobutyrique ou d'acide méthacrylique. L'organisme microbien contient au moins un acide nucléique exogène codant une enzyme dans une voie de synthèse d'acide 2-hydroxyisobutyrique, d'acide 3-hydroxyisobutyrique ou d'acide méthacrylique. L'invention concerne en outre un procédé de production d'acide 2-hydroxyisobutyrique, d'acide 3-hydroxyisobutyrique ou d'acide méthacrylique. Le procédé peut comprendre la culture d'un organisme microbien produisant de l'acide 2-hydroxyisobutyrique, de l'acide 3-hydroxyisobutyrique ou de l'acide méthacrylique, exprimant au moins un acide nucléique exogène codant une enzyme de la voie de synthèse d'acide 2-hydroxyisobutyrique, d'acide 3-hydroxyisobutyrique ou d'acide méthacrylique en une quantité suffisante, culture dans des conditions et pendant une durée suffisantes pour produire de l'acide 2-hydroxyisobutyrique, de l'acide 3-hydroxyisobutyrique ou de l'acide méthacrylique.
Burgard Anthony P.
Burk Mark J.
Osterhout Robin E.
Pharkya Priti
Genomatica Inc.
Smart & Biggar
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