Microorganisms for the production of tryptophan and process...

Details Microorganisms for the production of tryptophan and process... Microorganisms for the production of tryptophan and process...

C - Chemistry, Metallurgy

12

P

C12P 13/22 (2006.01) C12N 1/20 (2006.01) C12N 15/01 (2006.01) C12N 15/53 (2006.01)

Patent

CA 2145630

Microorganisms for the production of tryptophan and a process for producing the same are disclosed. These microorgan- isms are characterised by a deregulated tryptophan metabolism and by a feedback-resistant serA-allele deregulated serine metab- olism. When the disclosed strains were fermented, it has been surprisingly shown that the strains with the highest tryptophan yield are those which contain a feedback-resistant serA-allele with a K; value for serine from 100 µM to 50 mM and a deregulat- ed tryptophan metabolism having a trpE-allele with a K; value for tryptophan from 0.1 mM to 20 mM.

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