Microorganisms having attenuated invasiveness

Details Microorganisms having attenuated invasiveness Microorganisms having attenuated invasiveness

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/112 (2006.01) A61K 39/116 (2006.01) C07K 14/255 (2006.01) C12N 1/20 (2006.01) C12N 1/36 (2006.01) C12N 15/74 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2131369

2131369 9318165 PCTABS00025 The invention provides nucleic acids encoding one or more hyper-invasive genes within the hil locus (hyper-invasion locus) or fragments thereof, methods for making attenuated microorganisms and identifying such hyper-invasive nucleic acids as well as mutant microorganisms wherein one or more hyper-invasive genes within the hil locus are modified to attenuate the invasive phenotype of the microorganism. The methods of the invention utilize conditions which repress invasiveness in an otherwise invasive microorganism. The method comprises mutating an invasive microorganism to form a plurality of mutant microorganisms. The thus formed mutants are exposed to conditions which repress invasiveness of the parental invasive microorganism. At least one mutant microorganism is then detected which exhibits an increase in invasiveness as compared to the parental invasive microorganism. The site of mutation in the genome of the mutant microorganism is then determined to localize and identify one or more hyper-invasive genes within the hil locus of the invasive microorganism.

Affiliated with

Also associated with

Rating

Microorganisms having attenuated invasiveness does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microorganisms having attenuated invasiveness, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microorganisms having attenuated invasiveness will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1988039