Microoroganisms and cells for diagnosis and therapy of tumors

Details Microoroganisms and cells for diagnosis and therapy of tumors Microoroganisms and cells for diagnosis and therapy of tumors

C - Chemistry, Metallurgy

12

Q

C12Q 1/66 (2006.01) A61K 35/12 (2006.01) A61K 35/74 (2006.01) A61K 35/76 (2006.01) A61K 49/00 (2006.01) A61K 49/18 (2006.01) C12N 15/03 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2456055

Described are diagnostic and pharmaceutical compositions comprising a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g. a luminescent or fluorescent protein, or a protein inducing a signal detectable by magnetic resonance imaging (MRI) or a cell receptor capable of binding a ligand and, particular embodiment, furthermore (a) DNA sequence(s) encoding (a) protein(s) suitable for tumor therapy and/or elimination of metastatic tumors, e.g. a cytotoxic or cytostatic protein.

La présente invention concerne des compositions diagnostiques et pharmaceutiques comprenant un micro-organisme ou une cellule contenant une séquence d'ADN codant pour une protéine détectable ou une protéine susceptible d'induire un signal détectable, par exemple une protéine luminescente ou phosphorescente, et dans un mode de réalisation particulier, contenant en outre une ou des séquences d'ADN codant pour une ou des protéines aptes à la thérapie tumorale et/ou l'élimination de tumeurs métastasiques, par exemple une protéine cytotoxique ou cytostatique.

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