Microparticle containing matrices for drug delivery

Details Microparticle containing matrices for drug delivery Microparticle containing matrices for drug delivery

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61L 27/28 (2006.01)

Patent

CA 2636716

Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.

L'invention concerne des matrices polymères comprenant des microparticules produisant une libération prolongée d'un agent bioactif hydrophile. Les matrices peuvent être sous la forme d'un enrobage sur la surface d'un article médical implantable, ou d'une matrice formée in situ. Les microparticules de la matrice comprennent un premier polymère et un second polymère, ce dernier modulant la libération de l'agent bioactif hydrophile de la matrice.

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