Microparticle preparation and production thereof

Details Microparticle preparation and production thereof Microparticle preparation and production thereof

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 31/545 (2006.01) A61K 38/06 (2006.01) A61K 47/34 (2006.01) B01J 13/04 (2006.01)

Patent

CA 2101183

A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are at least partially or wholly coated with a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid, which acts as an agent for preventing aggregation of the microparticle preparation is disclosed. The preparation is produced by spraying a polymer solution containing a drug and a solution or dispersion of a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid from different nozzles and contacting them with each other in a spray dryer. In this procedure, if desired, a non-ionic surfactant may be added to the solution of the water-soluble inorganic salt, the water-soluble organic acid or the water- soluble salt of organic acid, or a solution of non-ionic surfactant may be sprayed from the other nozzle simultaneously.

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