Microparticles

A - Human Necessities – 61 – K

Patent

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A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2251987

The invention provides a process for the preparation of biodegradable biocompatible microparticles, said process comprising: contacting microparticles comprising a biodegradable biocompatible polymer matrix containing an active (e.g. pharmaceutical or diagnostic) agent and an organic solvent with an aqueous solvent system whereby the content of said organic solvent in said particles is reduced to 2 % or less of the weight of said particles said solvent system being such as to satisfy at least one of the conditions (a) that it is at an elevated temperature (e.g. from 25 to 40 °C) during at least pan of the time that it is in contact with said particles, and (b) that it comprises water and water-miscible solvent for said organic solvent; and recovering said particles from said aqueous solvent system.

La présente invention concerne un procédé de préparation de microparticules biodégradables et biocompatibles consistant à mettre en contact avec un système de solvants aqueux des microparticules comprenant une matrice de polymère biodégradable et biocompatible contenant une substance active (par exemple à usage pharmaceutique ou diagnostique) et un solvant organique, la teneur dudit solvant organique dans les particules étant réduite à 2 % ou moins du poids desdites particules. Ledit système de solvants doit remplir au moins l'une des conditions suivantes: (a) être à une température élevée (entre 25 et 40 DEG C par exemple) pendant au moins une partie du temps où il est en contact avec lesdites particules, et (b) comprendre de l'eau et un solvant miscible avec l'eau pour ledit solvant organique. La présente invention consiste ensuite à récupérer lesdites particules dudit système de solvants aqueux.

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