Microparticles for delivery of nucleic acid

Details Microparticles for delivery of nucleic acid Microparticles for delivery of nucleic acid

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/16 (2006.01) A61K 31/70 (2006.01) A61K 47/30 (2006.01) A61K 47/34 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2203857

Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.

L'invention porte sur la préparation de microparticules constituées d'une matrice polymérique et d'un vecteur d'expression d'acide nucléique. La matrice renferme un ou plusieurs polymères synthétiques, dont la solubilité dans l'eau est inférieure à environ 1 mg/l. Au moins 90 % des microparticules ont un diamètre inférieure à environ 100 microns. L'acide nucléique est soit de l'ARN, dont au moins 50 % se trouvent sous forme de cercles, soit de l'ADN plasmadique sous forme de molécules circulaires, dont au moins 50 % sont de type superhélicoïdal.

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