Microparticles for delivery of nucleic acid

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 9/16 (2006.01) A61K 9/66 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/205 (2006.01) A61K 39/29 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2276066

A preparation of microparticles made up of a polymeric matrix, a nucleic acid expression vector, and a lipid. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.

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