Microparticles for pulmonary administration

Details Microparticles for pulmonary administration Microparticles for pulmonary administration

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2380883

The invention concerns a biocompatible microparticle designed to be inhaled comprising at least an active principle and at least a layer coating said active particle which is the outer layer of said microparticle, said outer layer comprising at least a coating agent. The invention is characterised in that said microparticle has a mean diameter ranging between 1 µm and 30 µm, an apparent density ranging between 0.02 g/cm?3¿ and 0.8 g/cm?3¿ and it is obtainable by a method comprising essential steps which consist in bringing together a coating agent and an active principle and introducing a supercritical fluid, under agitation in a closed reactor.

La présente invention concerne une microparticule biocompatible destinée à être inhalée comprenant au moins un principe actif et au moins une couche enrobant ce principe actif qui est la couche externe de ladite microparticule, ladite couche externe contenant au moins un agent enrobant, caractérisée en ce que ladite microparticule possède un diamètre moyen compris entre 1 µm et 30 µm, une densité apparente comprise entre 0,02 g/cm3 et 0,8 g/cm3 et qu'elle est susceptible d'être obtenue selon un procédé comprenant les étapes essentielles qui sont la mise en présence d'un agent enrobant avec un principe actif et l'introduction d'un fluide supercritique, sous agitation dans un réacteur fermé.

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