C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 9/16 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01) C07K 14/02 (2006.01) C07K 14/105 (2006.01) C07K 14/16 (2006.01)
Patent
CA 2144425
The invention concerns the use, in the induction of an immune response, of a synthetic microparticle polymer carrying on the surface one or more covalently bonded proteins capable of carrying one or more epitopes, the densities of the protein(s) on the surface of the microparticles, and their molecular weights, being adjusted so as to direct the immune response to the induction of a humoral and cellular response or to the induction of a largely cellular response. Said microparticles have an average diameter of approximately 0.25 to 1.5 (my)m.
Utilisation pour l'induction d'une réponse immunitaire de microparticules en matériau synthétique polymère portant en surface une ou plusieurs protéines liées de manière covalente pouvant porter un ou plusieurs épitopes, les densités de la ou des protéines à la surface des microparticules, ainsi que leurs poids moléculaires, étant ajustées afin d'orienter la réponse immunitaire vers l'induction d'une réponse humorale et cellulaire ou vers l'induction d'une réponse majoritairement cellulaire. Les microparticules ont un diamètre moyen compris entre environ 0,25 et environ 1,5 µm.
Gengoux Christine
Leclerc Claude
Gowling Lafleur Henderson Llp
Institut Pasteur
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